Biosynthesis of conjugated linoleic acid in ruminants and humans. J Biochem.Mol.Biol 9-30-2002;35(5):494-497. In Vitro Cell Dev Biol Anim 2003;39(8-9):375-382. View abstract. Kim, H. K., Kim, S. R., Ahn, J. Y., Cho, I. J., Yoon, C. S., and Ha, T. Y. Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. J Food Sci 2008;73(1):T7-15. Obstet Gynecol 1981;58:68S-78S. Anticancer Res 1997;17(2A):969-973. Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid that are characterized by the presence of conjugated dienes. Studies on CLA have generally used doses of 3.2–6.4 grams per day. Changhua, L., Jindong, Y., Defa, L., Lidan, Z., Shiyan, Q., and Jianjun, X. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. Some of them are simply used for energy, while others have powerful health effects. J Lipid Res 2008;49(1):98-106. 2010;2010 View abstract. View abstract. J Nutr Biochem. Raff, M., Tholstrup, T., Basu, S., Nonboe, P., Sorensen, M. T., and Straarup, E. M. A diet rich in conjugated linoleic acid and butter increases lipid peroxidation but does not affect atherosclerotic, inflammatory, or diabetic risk markers in healthy young men. Brouwer, I. View abstract. 2020 Sep 24;30(10):1777-1784. doi: 10.1016/j.numecd.2020.05.029. O'Shea M, Stanton C, Devery R. Antioxidant enzyme defense responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. Gaullier, J. M., Halse, J., Hoye, K., Kristiansen, K., Fagertun, H., Vik, H., and Gudmundsen, O. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. The “conjugated” prefix has to do with the arrangement of the double bonds in the fatty acid molecule. 2007;2(10):e991. Weiler, H. A., Fitzpatrick, S., and Fitzpatrick-Wong, S. C. Dietary conjugated linoleic acid in the cis-9, trans-11 isoform reduces parathyroid hormone in male, but not female, rats. The effects of conjugated linoleic acid supplementation during resistance training. Cusack, S., Jewell, C., and Cashman, K. D. The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cells. Herbel BK, McGuire MK, McGuire MA, Shultz TD. 4-13-2009; View abstract. Lipids 1998;33(5):521-527. (Silver.Spring) 2008;16(5):1019-1024. Shultz, T. D., Chew, B. P., and Seaman, W. R. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Hubbard, N. E., Lim, D., Summers, L., and Erickson, K. L. Reduction of murine mammary tumor metastasis by conjugated linoleic acid. Liu, J., Chen, B., Liu, R., and Lu, G. [Inhibitory effect of conjugated linoleic acid on human gastric carcinoma cell line]. View abstract. Yun, H. S., Do, S. H., Jeong, W. I., Yang, H. J., Yuan, D. W., Hong, I. H., Lee, H. R., Lee, I. S., Kim, Y. K., Choi, M. S., Kim, H. A., and Jeong, K. S. Cytotoxic effects of the conjugated linoleic acid isomers t10c12, c9t11-CLA and mixed form on rat hepatic stellate cells and CCl4-induced hepatic fibrosis. Nutrition 2008;24(7-8):744-752. View abstract. Br J Nutr 2002;88(3):243-251. J Lipid Res 2003;44(7):1287-1300. View abstract. View abstract. View abstract. View abstract. Steck, S. E., Chalecki, A. M., Miller, P., Conway, J., Austin, G. L., Hardin, J. W., Albright, C. D., and Thuillier, P. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. J Nutr. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. A., Lynch, D. T., Tirrell, P. C., Tirrell, R. P., Sauer, L. A., Van der, Riet P., and Blask, D. E. Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids. Dairy products are a primary source of cis‐9, trans‐11‐CLA (c9,t11‐CLA), the most prevalent CLA isomer, in the diet of humans Am.J Clin.Nutr 2010;91(1):175-183. A., Treacher, D. F., and Turner, R. C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Cosmetics & Toiletries 2007;122(10):71-80. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). J Med Food 2010;13(1):13-19. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S., and Ezaki, O. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. J Nutr 2008;138(3):509-514. Purushotham, A., Shrode, G. E., Wendel, A. Riserus, U., Basu, S., Jovinge, S., Fredrikson, G. N., Arnlov, J., and Vessby, B. Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Int J Gynaecol Obstet 2005;91(3):221-227. View abstract. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Our website services, content, and products are for informational purposes only. View abstract. View abstract. Eur J Clin Nutr 2003;57(4):595-603. Anticancer Res 2006;26(1A):27-34. View abstract. J Agric.Food Chem 10-9-2002;50(21):6188-6193. Ebrahimi-Mameghani M, Jamali H, Mahdavi R, Kakaei F, Abedi R, Kabir-Mamdooh B. Conjugated linoleic acid improves glycemic response, lipid profile, and oxidative stress in obese patients with non-alcoholic fatty liver disease: a randomized controlled clinical trial. View abstract. Iranian Journal of Endocrinology & Metabolism 2010;12(1):84. Nutr Cancer 2002;44(2):203-212. Ribeiro AS, Pina FL, Dodero SR, et al. Arterioscler.Thromb.Vasc.Biol 2006;26(2):307-312. View abstract. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., and Pariza, M. W. Effect of conjugated linoleic acid on body composition in mice. Gaullier JM, Halse J, Hoye K, et al. Song, H. J., Sneddon, A. This graph shows how weight loss slows down over time: According to this paper, CLA can cause an average fat loss of 0.2 pounds (01. kg) per week for about six months. Br.J Nutr 2008;100(2):355-363. Cancer Lett 4-15-1992;63(2):125-133. View abstract. View abstract. View abstract. View abstract. Jenkins ND, Buckner SL, Cochrane KC, et al. This is a detailed review of glucomannan, a natural dietary fiber that has been shown to be an effective weight loss supplement. Learn how to tell the facts from fiction. 2002;28(2):79-86. The FDA allows CLA to be added to foods and gives it a GRAS (generally regarded as safe) status. View abstract. View abstract. Choi, J. S., Koh, I. U., Jung, M. H., and Song, J. CLA is a form of conjugated linoleic acid, and is a combination of the many different types of linoleic acid found naturally in nature. Jaudszus A, Mainz JG, Pittag S, et al. Artery 1997;22(5):266-277. View abstract. For high blood pressure: conjugated linoleic acid 4.5 grams per day along with ramipril (Altace) 37.5 mg/day has been used for 8 weeks. Recent advances in conjugated linoleic acid research. Dit levert extra mesomere stabiliteit voor de verbinding. View abstract. Lipids 2003;38(8):805-811. View abstract. Countless supplements on the market claim to offer a quick way to drop excess weight by suppressing your appetite. Lin, Y., Schuurbiers, E., Van, der, V, and de Deckere, E. A. Conjugated linoleic acid isomers have differential effects on triglyceride secretion in Hep G2 cells. A., Sehat, N., Mossoba, M. M., Kramer, J. K., Fritsche, J., Steinhart, H., and Ku, Y. Larsson, S. C., Bergkvist, L., and Wolk, A. Conjugated linoleic acid intake and breast cancer risk in a prospective cohort of Swedish women. Evans, N. P., Misyak, S. A., Schmelz, E. M., Guri, A. J., Hontecillas, R., and Bassaganya-Riera, J. Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. Lipids 2000;35(7):777-782. Storey, A., Rogers, J. S., McArdle, F., Jackson, M. J., and Rhodes, L. E. Conjugated linoleic acids modulate UVR-induced IL-8 and PGE2 in human skin cells: potential of CLA isomers in nutritional photoprotection. Venkatramanan, S., Joseph, S. V., Chouinard, P. Y., Jacques, H., Farnworth, E. R., and Jones, P. J. View abstract. Int J Obes.Relat Metab Disord 2001;25(8):1129-1135. In colorectal cancer cells in humans, CLA supplements have been seen to improve growth arrest by blocking the production of energy in cancer cells. Risks. Noone, E. J., Roche, H. M., Nugent, A. P., and Gibney, M. J. J Nutr 2006;136(4):992-997. A. Banni S, Angioni E, Casu V, et al. Kim, E. J., Kang, I. J., Cho, H. J., Kim, W. K., Ha, Y. L., and Park, J. H. Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. View abstract. Pariza, M. W., Park, Y., and Cook, M. E. The biologically active isomers of conjugated linoleic acid. A., de la Perriere, A. Hay fever. View abstract. Steinhart, H., Rickert, R., and Winkler, K. Identification and analysis of conjugated linoleic acid isomers (CLA). Whigham, L. D., Watras, A. C., and Schoeller, D. A. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. This survey is being conducted by the WebMD marketing sciences department. Smit, L. A., Baylin, A., and Campos, H. Conjugated linoleic acid in adipose tissue and risk of myocardial infarction. Riserus, U., Vessby, B., Arnlov, J., and Basu, S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans. Nakamura, Y. K. and Omaye, S. T. Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells. View abstract. View abstract. Murru E, Carta G, Cordeddu L, et al. J Nutr 2005;135(4):778-784. Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat-fed rats. Obes Res 2004;12(9):1435-1444. Effects of a dietary intervention with conjugated linoleic acid on immunological and metabolic parameters in children and adolescents with allergic asthma - a placebo-controlled pilot trial. View abstract. A double-blind randomized, placebo-controlled trial. Br.J Nutr 2007;97(2):273-280. View abstract. This information may not fit your specific health circumstances. If you’d believed the manufacturers’ exaggerated claims five to ten years ago, you would have thought CLA could literally melt fat from your body. Platt, I., Rao, L. G., and El Sohemy, A. Isomer-specific effects of conjugated linoleic acid on mineralized bone nodule formation from human osteoblast-like cells. Jiang J, Wolk A, Vessby B. View abstract. J Bone Miner.Res 1999;14(7):1153-1162. A., Santoli, D., and Kritchevsky, D. Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. View abstract. In other words, it’s technically a trans fat — but a natural type of trans fat that occurs in many healthy foods (4). Conjugated linoleic acids (CLA) are a family of at least 28 isomers of linoleic acid found mostly in the meat and dairy products derived from ruminants. Sluijs, I., Plantinga, Y., de Roos, B., Mennen, L. I., and Bots, M. L. Dietary supplementation with cis-9,trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults. View abstract. View abstract. Did you or will you purchase this product in-store or online? Purushotham, A., Wendel, A. Kloss, R., Linscheid, J., Johnson, A., Lawson, B., Edwards, K., Linder, T., Stocker, K., Petitte, J., and Kern, M. Effects of conjugated linoleic acid supplementation on blood lipids and adiposity of rats fed diets rich in saturated versus unsaturated fat. Kuniyasu, H., Yoshida, K., Sasaki, T., Sasahira, T., Fujii, K., and Ohmori, H. Conjugated linoleic acid inhibits peritoneal metastasis in human gastrointestinal cancer cells. An assessment of c9,t11 linoleic acid intake in a small group of young Canadians. Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. View abstract. 7-10-2001;168(1):15-21. An average diet supplies 15-174 mg of conjugated linoleic acid daily. View abstract. 2010;115(1):123-130. J Nutr 2005;135(8):1934-1939. Herrera, J. Where did you or where do you plan to purchase this product? Chao, P. M., Chen, W. H., Liao, C. H., and Shaw, H. M. Conjugated linoleic acid causes a marked increase in liver alpha-tocopherol and liver alpha-tocopherol transfer protein in C57BL/6 J mice. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. J Agric.Food Chem. J Nutr 2001;131(9):2316-2321. Diabetes Care 1999;22(9):1462-1470. Dauchy, R. T., Dauchy, E. M., Davidson, L. K., Krause, J. Paek, J., Kang, J. H., Kim, S. S., Son, K. A., Park, M. R., and Yang, M. P. Trans-10, cis-12 conjugated linoleic acid directly enhances the chemotactic activity of porcine peripheral blood polymorphonuclear neutrophillic leukocytes by activating F-actin polymerization in vitro. J Biol.Chem. J Neurochem. View abstract. Prostaglandins Leukot.Essent.Fatty Acids 2010;82(2-3):105-109. View abstract. View abstract. Int J Sport Nutr Exerc.Metab 2009;19(1):79-96. 6-12-2009;383(4):513-518. View abstract. Prostaglandins Leukot.Essent.Fatty Acids 2004;71(5):295-301. View abstract. Jung, J. I., Cho, H. J., Kim, J., Kwon, D. Y., and Park, J. H. trans-10,cis-12 conjugated linoleic acid inhibits insulin-like growth factor-I receptor signaling in TSU-Pr1 human bladder cancer cells. View abstract. For example, the CLA content is 300–500% higher in beef and dairy from grass-fed cows than grain-fed cows (9). The effects are most pronounced during the first six months, after which fat loss plateaus for up to two years. Supplemental doses are also much higher than the amounts people get from dairy or meat. View abstract. Meadus, W. J., MacInnis, R., and Dugan, M. E. Prolonged dietary treatment with conjugated linoleic acid stimulates porcine muscle peroxisome proliferator activated receptor gamma and glutamine-fructose aminotransferase gene expression in vivo. A., and Thompson, H. Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Diabetes Care 2002;25:1516-21. View abstract. Roman, J. L., Gonzalvez, A. View abstract. © 2005-2020 Healthline Media a Red Ventures Company. Conjugated linoleic acid is considered an anti-obesity agent believed to aid with weight loss, building muscle and endurance. Biochem.J 8-15-2007;406(1):77-83. McCarty, M. F. Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. PLoS.One. J Dairy Sci 2009;92(6):2662-2669. Truitt, A., McNeill, G., and Vanderhoek, J. Y. Antiplatelet effects of conjugated linoleic acid isomers. Conjugated linoleic acid and the control of cancer and obesity. A., Liu, L. F., and Belury, M. A. View abstract. However, the CLA found in supplements is made by chemically altering linoleic acid from vegetable oils. View abstract. Park, H. S., Chun, C. S., Kim, S., Ha, Y. L., and Park, J. H. Dietary trans-10, cis-12 and cis-9,trans-11 Conjugated Linoleic Acids Induce Apoptosis in the Colonic Mucosa of Rats Treated with 1,2-Dimethylhydrazine. Benito, P., Nelson, G. J., Kelley, D. S., Bartolini, G., Schmidt, P. C., and Simon, V. The effect of conjugated linoleic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. View abstract. Rahman, M. M., Bhattacharya, A., Banu, J., and Fernandes, G. Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice. Kelly, O., Cusack, S., Jewell, C., and Cashman, K. D. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. J Lipid Res 2009;50(3):467-476. Keep in mind that the CLA you find in supplements is not derived from natural foods but made by chemically altering linoleic acid found in vegetable oils (11). Palmquist DL, Lock AL, Shingfield KJ, Bauman DE. Lipids 1998;33(8):803-809. Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., and Calder, P. C. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. All rights reserved. 2003;133(1):257S-260S.View abstract. CLAs can be either cis-fats or trans-fats. View abstract. View abstract. View abstract. View abstract. Darestani, A. T., Hosseinpanah, F., Tahbaz, F., Amiri, Z., Darestani, R. T., and Hedayati, M. Effects of conjugated linoleic acid supplementation on body composition and leptin concentration in post-menopausal women. View abstract. View abstract. View abstract. Am.J Clin.Nutr 2010;91(5):1157-1164. Mediators.Inflamm. The biological activity of CLA was first discovered by researchers who noted that it could help fight cancer in mice (14). The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers. J Nutr 2003;133(2):456-460. Lee, J. H., Cho, K. H., Lee, K. T., and Kim, M. R. Antiatherogenic effects of structured lipid containing conjugated linoleic acid in C57BL/6J mice. View abstract. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. Basu, S., Smedman, A., and Vessby, B. Conjugated linoleic acid induces lipid peroxidation in humans. 4-22-2009;57(8):3164-3172. Nephron Exp.Nephrol. Epub 2020 Jun 8. View abstract. Ramirez-Santana, C., Castellote, C., Castell, M., Rivero, M., Rodriguez-Palmero, M., Franch, A., and Perez-Cano, F. J. Politis, I., Dimopoulou, M., Voudouri, A., Noikokyris, P., and Feggeros, K. Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. View abstract. Pariza M, Park Y, Cook ME. A., Barker, P. A., Bestwick, C., Choe, S. N., McClinton, S., Grant, I., Rotondo, D., Heys, S. D., and Wahle, K. W. Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells. Z. Many studies show that people who eat the most CLA have improved metabolic health and a lower risk of many diseases. A., Saebo, A., Lassel, T. S., Chardigny, J. M., Sebedio, J. L., and Mensink, R. P. Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B. Atherosclerosis 2006;188(1):167-174. Cunningham, D. C., Harrison, L. Y., and Shultz, T. D. Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. Spinach Extract: An Effective Weight Loss Supplement. Appl.Physiol Nutr Metab 2008;33(6):1096-1104. View abstract. Taking conjugated linoleic acid does not improve pre-meal or post-meal blood sugar or insulin levels in people with type 2 diabetes. View abstract. Chung, S., Brown, J. M., Sandberg, M. B., and McIntosh, M. Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. Michishita, T., Kobayashi, S., Katsuya, T., Ogihara, T., and Kawabuchi, K. Evaluation of the antiobesity effects of an amino acid mixture and conjugated linoleic acid on exercising healthy overweight humans: a randomized, double-blind, placebo-controlled trial. Cimini, A., Cristiano, L., Colafarina, S., Benedetti, E., Di Loreto, S., Festuccia, C., Amicarelli, F., Canuto, R. A., and Ceru, M. P. PPARgamma-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF). Kelley DS, Simon VA, Taylor PC, et al. The difference between these forms is that their double bonds are arranged in various ways. Fischer-Posovszky, P., Kukulus, V., Zulet, M. A., Debatin, K. M., and Wabitsch, M. Conjugated linoleic acids promote human fat cell apoptosis. View abstract. Stringer, D. M., Zahradka, P., Declercq, V. C., Ryz, N. R., Diakiw, R., Burr, L. L., Xie, X., and Taylor, C. G. Modulation of lipid droplet size and lipid droplet proteins by trans-10,cis-12 conjugated linoleic acid parallels improvements in hepatic steatosis in obese, insulin-resistant rats. Zhou, X. R., Sun, C. H., Liu, J. R., and Zhao, D. Dietary conjugated linoleic acid increases PPAR gamma gene expression in adipose tissue of obese rat, and improves insulin resistance. However, many studies show no effect at all (26, 27, 28). A rapid and sensitive screening system for human type I collagen with the aim of discovering potent anti-aging or anti-fibrotic compounds. 2007;232(2):246-252. View abstract. Diabetes. Yamasaki, M., Kitagawa, T., Chujo, H., Koyanagi, N., Nishida, E., Nakaya, M., Yoshimi, K., Maeda, H., Nou, S., Iwata, T., Ogita, K., Tachibana, H., and Yamada, K. Physiological difference between free and triglyceride-type conjugated linoleic acid on the immune function of C57BL/6N mice. Research on the effects of conjugated linoleic acid for improving strength is mixed. Biosci.Biotechnol.Biochem. View abstract. 3-13-2000;150(1):93-100. View abstract. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. View abstract. Adv Food Nutr Res 2005;50:179-217.View abstract. Cho, H. J., Lee, H. S., Chung, C. K., Kang, Y. H., Ha, Y. L., Park, H. S., and Park, J. H. trans-10, cis-12 conjugated linoleic acid reduces insulin-like growth factor-II secretion in HT-29 human colon cancer cells. Aryaeian, N., Shahram, F., Djalali, M., Eshragian, M. R., Djazayeri, A., Sarrafnejad, A., Naderi, N., Chamari, M., Fatehi, F., and Zarei, M. Effect of conjugated linoleic acid, vitamin E and their combination on lipid profiles and blood pressure of Iranian adults with active rheumatoid arthritis. Ringseis, R., Muller, A., Dusterloh, K., Schleser, S., Eder, K., and Steinhart, H. Formation of conjugated linoleic acid metabolites in human vascular endothelial cells. Conjugated linoleic acid (CLA), body fat, and apoptosis. Cancer Lett 6-24-1997;116(2):121-130. Conjugated linoleic acid (CLA) is a fatty acid found in meat and dairy that is believed to have various health benefits . Am J Physiol Endocrinol Metab 2009;297(1): E1-E9.View abstract. Anticancer Res 2005;25(6B):3943-3949. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Am J Clin Nutr 1999;70:21-7. Aspirin 4. Taking conjugated linoleic acid does not prevent or reduce symptoms of the common cold. Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Long-term feeding of the cis-9,trans-11 isomer of conjugated linoleic acid reinforces the specific immune response in rats. View abstract. As obesity increased worldwide, interest grew in CLA as a potential weight loss treatment. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Am J Clin Nutr 2001;73:807-814. Can CLA (Conjugated Linoleic Acid) Help You Lose Weight? Acide Linoléique Conjugué, Acide Linoléique Conjugué Cis-9,trans-11, Acide Linoléique Conjugué trans-10,cis-12, Acido Linoleico Conjugado, ALC, Cis-9,trans-11 Conjugated Linoleic Acid, Cis-Linoleic Acid, CLA, CLA-Free Fatty Acid, CLA-Triacylglycerol, LA, Linoleic Acid, Trans-10,cis-12 Conjugated Linoleic Acid. Jung, M. Y. and Jung, M. O. Iwata, T., Kamegai, T., Yamauchi-Sato, Y., Ogawa, A., Kasai, M., Aoyama, T., and Kondo, K. Safety of dietary conjugated linoleic acid (CLA) in a 12-weeks trial in healthy overweight Japanese male volunteers. Am J Clin Nutr 2005;82:894-900. Their two double bonds are conjugated (i.e., separated by a single bond). J Nutr 2009;139(7):1347-1352. A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (, Muscle strength. Macredmond R(1), Dorscheid DR. Diabetologia 1985;28(7):412-419. View abstract. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. J Strength.Cond.Res 2002;16(3):325-334. Br.J Nutr 2008;100(1):112-119. 1999;63(6):1104-1106. 2010;48(2):591-598. 2008;82(3):e23-e24. The main dietary sources of CLA are the meat and milk of ruminants, such as cows, goats and sheep. Kamphuis MM, Lejeune MP, Saris WH, Westerterp-Plantenga MS. Effect of conjugated linoleic acid supplementation after weight loss on appetite and food intake in overweight subjects. Ramirez-Santana, C., Castellote, C., Castell, M., Molto-Puigmarti, C., Rivero, M., Perez-Cano, F. J., and Franch, A. Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life. View abstract. View abstract. View abstract. Lipids 2001;36(3):221-227. Conjugated Linoleic Acid, or CLA for short, is a fatty acid that has taken the supplement world by storm. Advil (ibuprofen) 2. Nutr Res 2001;21:955-60. View abstract. J Dairy Sci 2007;90(9):4253-4264. View abstract. De La, Torre A., Debiton, E., Durand, D., Chardigny, J. M., Berdeaux, O., Loreau, O., Barthomeuf, C., Bauchart, D., and Gruffat, D. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Arch Anim Nutr 2005;59(6):429-438. Iranian Journal of Endocrinology & Metabolism 2009;11(2):221. Taylor, J. S., Williams, S. R., Rhys, R., James, P., and Frenneaux, M. P. Conjugated linoleic acid impairs endothelial function. Larsson SC, Bergkvist L, Wolk A. High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish Mammography Cohort. View abstract. Linoleic acid is the most common omega-6 fatty acid, found in large amounts in vegetable oils but also in various other foods in smaller amounts. View abstract. Lipids 2007;42(9):845-854. J Oleo Sci 2017;66(7):723-33. Elias SL, Innis SM. Physical activity and milk intake with conjugated linoleic acid (CLA) in healthy people with excess weight. Common cold. Kelly, O. and Cashman, K. D. The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomised rats. Perez-Matute, P., Marti, A., Martinez, J. View abstract. A., Siebelink, E., and Katan, M. B. Raff, M., Tholstrup, T., Toubro, S., Bruun, J. M., Lund, P., Straarup, E. M., Christensen, R., Sandberg, M. B., and Mandrup, S. Conjugated linoleic acids reduce body fat in healthy postmenopausal women. Atherosclerosis 2010;211(1):96-102. View abstract. 1999;348-353. They contain types of CLA never found in large amounts in nature (12, 13). A., Purushotham, A., Liu, L. F., and Belury, M. A. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. Numerous studies show that industrial trans fats — which are different from natural trans fats like CLA — are harmful when consumed in high amounts (5, 6, 7). 2008;19(3):175-183. Pal, S., Takechi, R., and Ho, S. S. Conjugated linoleic acid suppresses the secretion of atherogenic lipoproteins from human HepG2 liver cells. J.Sports Med.Phys.Fitness 2006;46(4):570-577. View abstract. View abstract. Revista Espanola de Obesidad 2007;5(2):109-118. J Nutr 2010;140(8):1454-1461. Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. View abstract. Kelly ML, Berry JR, Dwyer DA, et al. Bonet, S. B., Quintanar, R. A., Viana, A. M., Iglesias-Gutierrez, E., and Varela-Moreiras, G. The effects of yogurt with isomer enriched conjugated linoleic acid on insulin resistance in obese adolescents. Found in Beef and Dairy — Particularly From Grass-Fed Animals, Large Doses May Cause Serious Side Effects. Ryder, J. W., Portocarrero, C. P., Song, X. M., Cui, L., Yu, M., Combatsiaris, T., Galuska, D., Bauman, D. E., Barbano, D. M., Charron, M. J., Zierath, J. R., and Houseknecht, K. L. Isomer-specific antidiabetic properties of conjugated linoleic acid. View abstract. Tarnopolsky, M., Zimmer, A., Paikin, J., Safdar, A., Aboud, A., Pearce, E., Roy, B., and Doherty, T. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. Am.J Clin.Nutr 2010;92(1):34-40. Carvalho RF, Uehara SK, Rosa G. Microencapsulated conjugated linoleic acid associated with hypocaloric diet reduces body fat in sedentary women with metabolic syndrome. Aryaeian, N., Shahram, F., Djalali, M., Eshragian, M. R., Djazayeri, A., Sarrafnejad, A., Salimzadeh, A., Naderi, N., and Maryam, C. Effect of conjugated linoleic acids, vitamin E and their combination on the clinical outcome of Iranian adults with active rheumatoid arthritis. Vitamin K2 no information for conjugated linoleic acid be statistically significant, are! Time to supplement asthma therapy oil actually help you lose stubborn belly fat and control your appetite C.... Ilich, j obese men with the euglycemic insulin clamp or fatigue in taking! A. P., and fatigue weight — but is that true laso, N. Y. Valacchi. Pariza, M. j Y. and Jung, M. H., Rickert, R. L. conjugated linoleic acid on metabolism... 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